Effects of selenium on metabolism of mercuric chloride.

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Abstract
Hg and Se distribution in subcellular fractions was examined for the effects of Se on metabolism of HgCl2 in rats. The subcellular Hg and Se distribution was changed greatly with their concurrent administration and decreased in soluble fraction and increased in nuclei and debris fractions. With the administration of Hg alone, 53% was in the soluble fraction and only 1% of Hg was in the soluble fraction with the concurrent administration of Hg and Se. The molar ratio of Hg to Se was about 1:1 in nuclei and debris, mitochondria and microsomes fractions, respectively. Hg in nuclear fraction prepared by the method of Chanda and others with the concurrent administration of Hg and Se, was 9 .times. that with the administration of Hg alone. Insoluble nonhistone protein fraction from nuclear fraction had 60% of Hg and in this fraction the amount of Hg/mg protein with the concurrent administration of Hg and Se was about 13 .times. that with the administration of Hg alone. The behavior of Hg and Se was also examined in the plasma. Hg and Se accumulated in the ratio of 1:1 in the plasma. The gel filtration pattern of Hg in plasma protein on Sephadex G-200 chromatography was changed greatly and most Hg was accumulated in some protein of high molecular fraction with the concurrent administration of Hg and Se.

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