Beware of Surrogate Outcome Measures
- 1 January 1996
- journal article
- research article
- Published by Cambridge University Press (CUP) in International Journal of Technology Assessment in Health Care
- Vol. 12 (2) , 238-246
- https://doi.org/10.1017/s0266462300009594
Abstract
Surrogate outcome measures may speed up clinical research if they can be measured earlier in a study than the primary outcome of interest. We review the justification for their use and conclude that reliance on them may be harmful. Results obtained with surrogates should therefore be regarded as preliminary. Large, definitive trials with clinically relevant outcomes should always be performed before new interventions are accepted.This publication has 25 references indexed in Scilit:
- The Association Between β-Agonist Use and Death From AsthmaJAMA, 1993
- The association between beta-agonist use and death from asthma. A meta-analytic integration of case-control studiesPublished by American Medical Association (AMA) ,1993
- Randomized Clinical Trials on Medical Treatment of GlaucomaArchives of Ophthalmology (1950), 1993
- A Comparison of Results of Meta-analyses of Randomized Control Trials and Recommendations of Clinical ExpertsJAMA, 1992
- A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarctionJAMA, 1992
- Relationship Between Intraocular Pressure and Primary Open Angle Glaucoma Among White and Black AmericansArchives of Ophthalmology (1950), 1991
- Minimizing the Three Stages of Publication BiasJAMA, 1990
- Minimizing the three stages of publication biasJAMA, 1990
- Quantification and monitoring of visual field defects and a prospective, randomized comparison of pilocarpine and timolol using computerized perimetry (summary)Survey of Ophthalmology, 1989
- Surrogate endpoints in clinical trials: Ophthalmologic disordersStatistics in Medicine, 1989