EFFECT OF SODIUM NITROPRUSSIDE-INDUCED HYPOTENSION ON PULMONARY DEADSPACE

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Abstract
Deliberate hypotension with nitroprusside produced a 40% reduction in mean arterial pressure, but it did not cause any change in the pulmonary deadspace to tidal volume ratio (VD/VT). This was achieved by adequate hydration both before and during hypotension, as indicated by constant filling pressures. Thus we have shown that deliberate hypotension per se does not increase VD/VT, and that vasodilataaon may bring about a relatively hypovolaemic state and be responsible for the increase in VD/VT observed by previous workers

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