Ibuprofen-like activity in extra-virgin olive oil
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- 31 August 2005
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 437 (7055) , 45-46
- https://doi.org/10.1038/437045a
Abstract
Newly pressed extra-virgin olive oil contains oleocanthal — a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen1. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.Keywords
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