TOLBUTAMIDE HYPOGLYCEMIA IN ACUTELY DEPANCREATIZED DOGS*†

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Abstract
The administration of tolbutamide to 7 dogs in acute experiments within 2 to 10 minutes after removal of the pancreas showed a distinct hypoglycemic effect. Blood sugar rise during the 1st two hours after pancreatectomy was less than in dogs who did not receive tolbutamide. Distinct fall in blood sugar after tolbut-amide administration occurred in 2 to 4 hours. When the administration of tolbutamide was delayed for 1 to 2 hours (4 dogs), blood sugar fall did not occur in 2, was equivocallin 1 and definite in the 4th. The hypoglycemic effects noted could not be mediated through the pancreas. The data are consistent with the concept that tolbutamide hypoglycemia requires the presence of some insulin, such as the endogenous insulin still present in these animals.