Pulsatile secretion of LH in women

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Abstract
In 1971 Midgeley & Jaffe published data suggesting that the plasma concentration of gonadotrophins in normal women varied in a pulsatile fashion. This observation has been confirmed subsequently and considerable effort has been directed at defining the nature and origin of the pulsatile pattern of gonadotrophin secretion in the normal and abnormal ovarian cycle. Results of these studies have shown that systemic pulses of luteinizing hormone (LH) appear to be the consequence of pulsatile stimulation of the gonadotroph by LH-releasing hormone (LHRH) in the pituitary portal capillary system (Clarke & Cummins, 1982). The major source of this pulsatile release of LHRH is the arcuate nucleus of the mediobasal hypothalamus, which is in turn controlled by higher centres in the brain. This electrophysiological control mechanism is modified by a number of factors, such as noradrenaline, endorphin and vasoactive intestinal peptide, all of which have been shown to alter the LH pulse

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