Gradient Plate Technique Applied to the Study of Antiviral Substances.

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Abstract
Summary The gradient plate technique, originally used in bacteriology, was adapted to the study of virus inhibition by known antiviral compounds, including pyrimidine nucleo-sides, thiosemicarbazones, amantadine, guanidine, and -hydroxybenzylbenzimidazole, all of which produced striking antiviral effects. Reversal of 5-iodo-2′-deoxyuridine (IUdR) activity by thymidine was readily quantified by using this method. The technique was applicable to the bioassay of IUdR and guani-dine and to the ready detection and isolation of IUdR-resistant strains of herpes simplex virus.

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