THE RELATION OF CALCIUM CONTENT TO ACIDITY AND BUFFER VALUE OF GASTRIC SECRETIONS

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Abstract
Analysis of 15-min. samples of gastric secretions obtained under a var. of conditions in acute expts. in dogs showed a reciprocal relationship between Ca conc. and acidity. This relationship was seen when the levels of Ca and acidity found after establishment of a constant rate of secretion of either the histamine or the vagus type were compared in 24 animals; after the intraven. inj. of Ca salts (29 injs. in 17 animals); and in single expts. when vagal and histamine stimuli were used alternately. In the last type of expt. the high acidity characteristic of histamine secretion was accompanied by a low Ca conc. while the relatively low acidity characteristic of vagal secretion was accompanied by high Ca values. These variations were not dependent on vol. changes. The Ca output increased when the vagal secretion replaced the histamine in individual expts. and after the period of inhibition caused by Ca inj. The ratio total acidity/free acidity, which is interpreted as an index of the buffer value, varied directly with the Ca conc.

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