Latent Meiotic Anomalies Related to an Ancestral Exposure to a Mutagenic Agent
- 9 April 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3979) , 171-174
- https://doi.org/10.1126/science.172.3979.171
Abstract
When urethan is administered to cytologically normal F2 progeny descended from grandsires exposed to ethyl methanesulfonate, meiotic anomalies in the forms of site-specific X-chromosome deletions and bivalent associations are noted in spermatocytes of male Armenian hamsters examined 6 and 8 days after treatment, respectively. These latent anomalies are initiated and retained in a premutated state for two generations after the ancestral exposure to ethyl methanesulfonate, the additional impetus required to complete the mutational processes being supplied by urethan.Keywords
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