PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA ASSOCIATED WITH INFECTIOUS-MONONUCLEOSIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (2) , 351-353
Abstract
A previously healthy 16 yr old girl had pancytopenia, low reticulocyte count, a cellular bone marrow and a negative Coombs test, all coincident with clinical and laboratory evidence of infectious mononucleosis. Symptoms and signs of infectious mononucleosis subsided but pancytopenia and hemolytic anemia persisted. Sucrose hemolysis and acid hemolysis tests supported a diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). After 18 mo., the platelet count is normal but leukopenia and hemolytic anemia continue. PNH in this patient may have resulted from an effect of infectious mononucleosis.

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