Amplification of the epidermal growth factor receptor gene in the BT20 breast carcinoma cell line
- 15 August 1987
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 40 (2) , 189-191
- https://doi.org/10.1002/ijc.2910400210
Abstract
Southern blot-hybridization analysis of 10 breast carcinoma cell lines demonstrated an amplification of the epidermal growth factor (EGF) receptor gene in the BT20 cell line. The gene was amplified 10-to 14-fold when compared to the level seen in human placental DNA. Northern blot analysis indicated an increased level of transcription in this cell line which probably accounts for the high level of the EGF receptor reported in the BT20 cell line.This publication has 15 references indexed in Scilit:
- Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu OncogeneScience, 1987
- Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial originNature, 1985
- Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease StageScience, 1984
- Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cellsNature, 1984
- Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsNature, 1984
- Amplification and Enhanced Expression of the Epidermal Growth Factor Receptor Gene in A431 Human Carcinoma CellsScience, 1984
- Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequencesNature, 1984
- TECHNOLOGICAL EXAMINATION OF LOW‐FIRED TERRACOTTA STATUES FROM AYIA IRINI, KEAArchaeometry, 1982
- Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.Journal of Biological Chemistry, 1980