Renal Transplantation in Systemic Lupus erythematosus
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 27 (4-5) , 197-201
- https://doi.org/10.1159/000182053
Abstract
3 patients with chronic renal failure due to lupus nephritis received kidney allografts from cadaver donors. Serological activity was present in 2 patients at the time of transplantation, and continued unabated despite intensive immunosuppressive therapy. Their allograft failed at 5 and 7 months after transplantation. Anti-DNA antibody in the allograft was found in 1 patient. The 3rd patient, with no serological activity at the time of transplantation, remained serologically negative, and her allograft functioned for 18 months. The persistence of serological activity in 1 patient, and the recovery of anti-DNA antibody from her allograft provide proof for the recurrence of lupus nephritis in the allograft.Keywords
This publication has 4 references indexed in Scilit:
- Immunologic Factors and Clinical Activity in Systemic Lupus ErythematosusNew England Journal of Medicine, 1968
- THE ROLE OF ANTI-GLOMERULAR BASEMENT MEMBRANE ANTIBODY IN THE PATHOGENESIS OF HUMAN GLOMERULONEPHRITISThe Journal of Experimental Medicine, 1967
- The significance of antinuclear factors in rheumatoid arthritisArthritis & Rheumatism, 1965
- Complement Fixation with Cell Nuclei and DNA in Lupus ErythematosusExperimental Biology and Medicine, 1957