RNA sequence and the nature of the CuA‐binding site in cytochrome c oxidase
- 30 July 1990
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 268 (1) , 5-7
- https://doi.org/10.1016/0014-5793(90)80958-l
Abstract
For cytochrome c oxidase subunit II (COXII), DNA and protein sequences suggest that Met-207 (bovine numbering) is conserved in all species except plants. Sequencing of plant mitochondrial COXII mRNAs now indicates that Met-207 is also conserved among plants as a result of a C-to-U type of RNA editing. Considering the strict evolutionary conservation of Met-207 and the homology of COXII to type I (blue) copper proteins and nitrous oxide reductase, we propose a model in which Met-207 is associated with the CuA-binding site (along with Cys-196, Cys-200 and His-204) and plays a role in determining its reduction potential and stability.Keywords
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