The Structures of Cytotoxic Diterpenes Containing Bromine from the Marine Red Alga Laurencia obtusa (Hudson) Lamouroux
- 1 November 1990
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 63 (11) , 3066-3072
- https://doi.org/10.1246/bcsj.63.3066
Abstract
Four new brominated diterpenes possessing parguerane or isoparguerane skeleton have been isolated from the title alga collected in the Japanese waters along with several known parguerol, isoparguerol, and deoxyparguerol congeners. The structures of three new compounds were determined by the chemical correlation with the corresponding known compounds. The structural elucidation of the remaining one was carried out on the basis of a combination of chemical and spectroscopic means including 2D NMR technique. One of the new metabolites has proved to be cytotoxic. The cytotoxic properties of the several chemically derived compounds in addition to the known diterpenes are also described.This publication has 5 references indexed in Scilit:
- Structure elucidation of the antibiotic desertomycin through the use of new two-dimensional NMR techniquesJournal of the American Chemical Society, 1986
- Proton and carbon-13 assignments from sensitivity-enhanced detection of heteronuclear multiple-bond connectivity by 2D multiple quantum NMRJournal of the American Chemical Society, 1986
- Teurilene and thyrsiferyl 23-acetate, meso and remarkably cytotoxic compounds from the marine red alga laurencia obtusa (hudson) lamourouxTetrahedron Letters, 1985
- Marine natural products: parguerol, deoxyparguerol, and isoparguerol. New brominated diterpenes with modified pimarane skeletons from the sea hare Aplysia dactylomelaJournal of the American Chemical Society, 1982
- A diterpene from Laurencia obtusaPhytochemistry, 1982