A double blind comparison of lofepramine, imipramine and placebo in patients with primary depression

Publisher Website
Google Scholar
Abstract
The results of a double-blind trial in which 139 patients with primary depression were randomly assigned to either lofepramine (46), imipramine (48) or placebo (45) are discussed. After treatment with either active drug, lofepramine or imipramine, the clinical outcome was significantly greater than with placebo. No significant differences were found in clinical responses between lofepramine and imipramine. With regard to reported side effects, a statistically significant lower number of severe and/or moderate side effects were reported for the lofepramine group than for the imipramine group. In particular, for severe and/or moderate occurrences of dry mouth, the statistically significant lower incidence of favor of lofepramine is by almost a factor of 3 (8 lofepramine vs. 21 imipramine patients).

This publication has 8 references indexed in Scilit: