Null cell adenomas of the pituitary gland. An immunohistochemical study

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Abstract
Fourteen null cell adenomas of the pituitary gland were examined immunohistochemically with antisera against three general neuroendocrine markers and 22 hormones. All cases showed positive immunostaining for neuron-specific enolase, ten cases for synaptophysin, and six cases expressed chromogranin immunoreactivity. Hormone immunoreactivity was detected in a few cells in ten of the 14 cases studied and the number of hormones demonstrated in each case was one or two, Thyroid-stimuating hormone was detected in five of the 14 cases, gastrin in four, β-endorphin in two, calcitonin gene related peptide in one, prolactin in one, and follicle-stimulating hormone in one.