Exchange of I131‐Albumin in Acute Inflammatory Oedema

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Abstract
The shift of protein between plasma and experimentally induced inflammatory oedema has been studied in mice after intravenous injection of radioiodinated human serum albumin. Calculations were based on the difference between the total amounts or radioactivity in inflamed skin samples and self control samples of equal surface areas. It was demonstrated that during the initial 15 min of the inflammatory process the oedema contained less radioactivity per unit weight than the plasma. Subsequent to this point, however, the activity increments of the inflamed tissue could be accounted for in terms of extravasated plasma. It was further shown that human serum albumin injected intravenously to mice disappears from the plasma according to a linear function in a semilogarithmic system. The disappearance half time was 99 min in control animals but 32 min in mice with localized inflammatory oedema. The average plasma volume of mice weighing 25 g was 1,1 ml as determined by means of radioiodinated human serum albumin.