Protein aggregation in crowded environments
Top Cited Papers
- 1 January 2006
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 387 (5) , 485-97
- https://doi.org/10.1515/bc.2006.064
Abstract
The generic tendency of proteins to aggregate into non-functional, and sometimes cytotoxic, structures poses a universal problem for all types of cell. This tendency is greatly exacerbated by the high total concentration of macromolecules found within most intracellular compartments, a phenomenon referred to as macromolecular crowding. This review discusses the quantitative effects of crowding on protein aggregation and the role of molecular chaperones in combating this problem.Keywords
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