Guanosine Triphosphate Activation of Brain Adenylate Cyclase: Enhancement by Long-Term Antidepressant Treatment

7 January 1983

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 219 (4580) , 65-67
https://doi.org/10.1126/science.6849117

Abstract

Activation of adenylate cyclase by a stable guanosine 5'-triphosphate analog was augmented in brain membrane preparations from rats treated on a long-term basis with tricyclic antidepressants or electroconvulsive shock. These treatments may facilitate cyclase activation by promoting the interaction of the regulatory and catalytic subunits of the enzyme. This finding suggests a possible mechanism for the changes in sensitivity to various neurotransmitters seen after antidepressant administration.

Keywords

This publication has 29 references indexed in Scilit:

Chronic antidepressant treatment enhances α-adrenergic and serotonergic responses in the facial nucleus
Life Sciences, 1980
Biochemical Properties of Hormone-Sensitive Adenylate Cyclase
Annual Review of Biochemistry, 1980
Swedes vote on their nuclear future
Nature, 1980
Adrenergic Subsensitivity of a Cell‐free Adenylate Cyclase from Rat Brain after Chronic Imipramine Treatment
Archiv der Pharmazie, 1980
The effect of repeated administration of antidepressant drugs on the responsiveness of rats to catecholamine agonists
Journal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1979
Inhibition of platelet adenylate cyclase by epinephrine requires GTP
FEBS Letters, 1978
Development of β-adrenergic receptor subsensitivity by antidepressants
Nature, 1977
Influence of injected psychoactive drugs on cyclic amp levels in mouse brain and lung following microwave irradiation
Neuropharmacology, 1977
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Analytical Biochemistry, 1976
REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I
Journal of Neurochemistry, 1966