The Hill Plot and the Energy of Interaction in Hemoglobin
- 17 March 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4027) , 1253-1255
- https://doi.org/10.1126/science.175.4027.1253
Abstract
The Hill plot does not independently yield the average free energy of interaction per binding site, as has been proposed by Wyman, but rather the difference between the free energies of interaction on binding the first and last ligands. It is shown that additional data (or assumptions) and a model for cooperative behavior are required to obtain the average free energy of interaction.Keywords
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