Anti‐viral immunity against Marek's disease virus infected chicken kidney cells

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Abstract
The mechanism of immunity conferred by herpesvirus of turkeys (HVT) was investigated using Marek''s disease virus (MDV)-infected chicken kidney cell (CKC) cultures as target cells. Peripheral blood lymphocytes (PBL) from normal or HVT-vaccinated chickens killed MDV-infected target cells in the presence of anti-MDV or anti-HVT serum, whereas normal lymphocytes and HVT-sensitized lymphocytes themselves had no specific cytotoxic effect. Cell-mediated cytotoxicity of PBL from HVT-vaccinated chickens was exhibited specifically against HVT-infected CKC, and that of PBL from chickens inoculated with MDV was exhibited against MDV-infected CKC. Antibody-dependent cellular cytotoxicity to MDV-infected cells may contribute to resistance to Marek''s disease induced by HVT vaccination.