Biochemical Studies of Erythrocytes in a Patient with Pyroglutamic Acidemia (5-Oxoprolinemia)

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Abstract
An adult with pyroglutamic acidemia was investigated biochemically in efforts to explain his overproduction of pyroglutamate and his neurologic disease. The patient's erythrocytes contained no detectable glutathione, and their glutathione synthetase activity was less than 2 per cent of normal. These cells were loaded with free amino acids, most of them in concentrations five to 100 times normal. The erythrocytes also contained the unusual compound methionine sulfoxide. In skeletal muscle, in which glutathione was only reduced to 3 per cent of normal, there was no amino acid accumulation.