Efficacy, Potential and Hazards of Vaccines

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Abstract
RAPIDLY accumulating knowledge, as yet incomplete and only partially understood, of the varied effects on host cells and tissues of infectious agents renders increasingly difficult a dispassionate and judicious evaluation of the benefits and risks inherent in any vaccine. Great strides have been made in the development and application of technics ensuring consistent and reliable production of large quantities of such antigens, both live and killed, that satisfy existing standards for safety and efficacy. Unfortunately, but understandably, these advances in methodology have been achieved more rapidly than the acquisition of information pertinent to those effects, other than immunologic, of such . . .