Behavioural similarities between mother rats and benzodiazepine-treated non-meternal animals
- 1 January 1985
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 86 (3) , 344-347
- https://doi.org/10.1007/bf00432226
Abstract
Mother rats nursing large litters are hyperphagic, aggressive towards conspecifics, and show less freezing behaviour than non-maternal animals. These naturally occurring adaptations resemble those elicited by benzodiazepine treatment in virgin rats, indicating a common neurochemical change in the brains of mother rats and benzodiazepine-treated virgins. In line with this hypothesis, it was found that three functional benzodiazepine antagonists (FG 7142, pentylenetetrazol, caffeine) decreased food intake, lowered aggression and strengthened freezing in lactating mother rats. These psychopharmacological observations support the idea that GABA neurotransmission is enhanced during motherhood in the rat.Keywords
This publication has 29 references indexed in Scilit:
- Reduced fearfulness in the lactating ratPhysiology & Behavior, 1985
- DOPAMINE RECEPTORS AND SECOND MESSENGERSClinical Neuropharmacology, 1984
- Influence of castration and brain GABA levels in three strains of mice on aggression towards lactating intrudersPhysiology & Behavior, 1984
- Ro 15-1788 and β-CCE selectively eliminate diazepam-induced feeding in the rabbitPharmacology Biochemistry and Behavior, 1984
- The neuropharmacology of various diazepam antagonistsNeuropharmacology, 1983
- Bicuculline blocks diazepam-induced feeding in Syrian hamstersLife Sciences, 1982
- Muscimol induced feeding: A model to study the hypothalamic regulation of appetiteLife Sciences, 1981
- Caffeine antagonizes several central effects of diazepamLife Sciences, 1981
- Postpartum aggression in rats: I. Effects of hypophysectomy.Journal of Comparative and Physiological Psychology, 1980
- Benzodiazepine-induced voraciousness in cats and inhibition of amphetamine-anorexiaLife Sciences, 1976