Pulmonary cytomegalovirus infection: detection by Gallium 67 imaging in the transplant patient

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Abstract
Cytomegalovirus (CMV) infection is a frequent complication during the first few months following renal transplantation. The diagnosis is sometimes difficult but may be made by viral culture, a 4-fold rise in the CMV antibody titer or by demonstration of the CMV inclusions in the affected tissue. An increased pulmonary uptake of gallium citrate Ga 67 was demonstrated following renal transplantation in 2 patients, each of whom had a 4-fold rise in CMV complement fixing antibody titer, one of whom additionally had CMV inclusion bodies in a lung biopsy specimen prior to clinical or radiological demonstration of the pulmonary involvement. Gallium imaging appears to be a valuable noninvasive test for early diagnosis of CMV pulmonary infections.

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