Abstract
Studies on the merits of vitamin E therapy were made in 66 patients who complained of the characteristic vasomotor symptoms of the menopause. The daily dose of Ephynal Acetate ranged from 20 to 100 mg., with an avg. of 30 mg. in divided doses. Good to excellent results were obtained in 31 women (47%); fair results in 16 (24.2%); and in 19 patients (28.8%), the treatment was ineffectual. Discontinuation of the vitamin E prepn. resulted in recurrence of symptoms. Reinstitution of the medication was again attended by prompt relief. Substitution of placebo medication for the vitamin E preparation in 17 patients caused a recurrence of symptoms. Side effects from the vitamin E therapy were negligible and there were no contraindications of its use. It is concluded that vitamin E is a valuable aid in the treatment of menopausal patients in whom estrogens are contraindicated such as women with a familial or personal history of mammary or genital malignancy or patients suffering from precancerous lesions.

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