microRNAs join the p53 network — another piece in the tumour-suppression puzzle
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- 1 November 2007
- journal article
- research article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 7 (11) , 819-822
- https://doi.org/10.1038/nrc2232
Abstract
Several recent papers have shown that the miR-34 family of microRNAs is directly involved in mediating the effects of p53, indicating that non-coding RNAs have an important role in tumorigenesis. This Progress article discusses these papers and their implications. Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.Keywords
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