The chemical repertoire of natural ribozymes
Top Cited Papers
- 11 July 2002
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 418 (6894) , 222-228
- https://doi.org/10.1038/418222a
Abstract
Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have intrinsic enzyme-like activity — they can catalyse chemical reactions in the complete absence of protein cofactors. In addition to the well-known small ribozymes that cleave phosphodiester bonds, we now know that RNA catalysts probably effect a number of key cellular reactions. This versatility has lent credence to the idea that RNA molecules may have been central to the early stages of life on Earth.Keywords
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