Cardiovascular Research in Pregnancy: The Role of Animal Models
- 1 January 1993
- journal article
- review article
- Published by Taylor & Francis in Hypertension in Pregnancy
- Vol. 12 (3) , 413-437
- https://doi.org/10.3109/10641959309042862
Abstract
Because of ethical constraints upon research during human pregnancy, animal species have been used to model both the physiological adaptation to pregnancy and the pathophysiology of preeclampsia. This review examines these applications in animals such as rats, guinea pigs, rabbits, dogs, and sheep. However, the main thrust of this review is to look at studies in the baboon and explore the contribution of this large Old World primate in furthering our understanding of human pregnancy.Keywords
This publication has 46 references indexed in Scilit:
- Effect of endothelin-1 on the uterine vasculature of the pregnant and estrogen-treated nonpregnant sheepAmerican Journal of Obstetrics and Gynecology, 1992
- Angiotensin II vascular smooth-muscle receptors are not down-regulated in near-term pregnant sheepAmerican Journal of Obstetrics and Gynecology, 1991
- Pregnancy‐induced hypertension: pathogenesis and managementAustralian and New Zealand Journal of Medicine, 1991
- Pathogenesis of Pregnancy-Induced Hypertensive Disorders A Review of Experimental Animal ModelsClinical and Experimental Hypertension. Part B: Hypertension in Pregnancy, 1991
- Decreased Pressor Responsiveness in Pregnancy: Studies in Experimental AnimalsAmerican Journal of Kidney Diseases, 1987
- In vitro prostacyclin production by ovine uterine and systemic arteries. Effects of angiotensin II.Journal of Clinical Investigation, 1985
- The pregnant rabbit, guinea pig, sheep and rhesus monkey as models in reproductive physiologyEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 1984
- The chronically instrumental ewe: a model for studying vascular reactivity to angiotensin II in pregnancy.Journal of Clinical Investigation, 1981
- Circulatory response to systemic infusion of norepinephrine in the pregnant eweAmerican Journal of Obstetrics and Gynecology, 1977
- Major and collateral components of blood flow to pregnant sheep uterusAmerican Journal of Physiology-Legacy Content, 1975