Metabolism of Pregnenolone and Pregnenolone Sulphate in Benign Essential Hypertension

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Abstract
Patients with benign essential hypertension excreted in their urine less of the radioactive label associated with the injected tracer 3H-pregnenolone sulphate than control subjects, but more of the label associated with the 14C-pregnenolone tracer. In both groups, there was no difference in the urinary production rate of pregnenolone. Patients with benign essential hypertension had a higher production rate of pregnenolone sulphate. The 3H/14C ratio in the urinary metabolites pregnenediol glucuronide and sulphate were higher in control subjects. There was no difference in the excretion of pregnenediol, 17α-hydroxypregnenolone and pregnenetriol conjugates except for pregnenetriol sulphate which was found markedly lower in patients.