Role of Gamma Interferon inHelicobacter pyloriInduction of Inflammatory Mediators during Murine Infection
Open Access
- 1 June 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (6) , 3295-3299
- https://doi.org/10.1128/iai.70.6.3295-3299.2002
Abstract
Gamma interferon (IFN-γ) has been proposed to play an important role in Helicobacter-related gastritis. Using the IFN-γ gene knockout (IFN-γ−/−) mouse model and a murine gastric epithelial cell line, GSM06, we demonstrated that Helicobacter pylori maximally induced macrophage inflammatory protein-2 (MIP-2) and inducible nitric oxide synthase (iNOS) mRNA only in wild-type mice. MIP-2 and iNOS mRNA were also induced by H. pylori in GSM06 cells. Induction of cyclooxygenase 2 mRNA through IFN-γ was demonstrated in GSM06 cells. These data indicate that IFN-γ mediates the induction of MIP-2 and iNOS mRNA expression by H. pylori in mice.Keywords
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