Comparative Study of Seven Picornaviruses of Man

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Abstract
Jamison, RichardM. (Baylor University College of Medicine, Houston, Tex.),and Heather D. Mayor. Comparative study of seven picornaviruses of man. J. Bacteriol.91:1971–1976. 1966.—The buoyant densities in CsCl and potassium tartrate of seven acid-resistant picornaviruses of man were determined. The viruses studied were found to be a relatively homogeneous group. Buoyant densities ranged from 1.32 to 1.35 g/cc in CsCl and 1.21 to 1.23 g/cc in potassium tartrate. The buoyant density of each virus did not vary by more than 0.01 g/cc. The host cell of origin and passage level did not influence the buoyant density of the virions. However, measurements of the diameters of purified virions by a standard method have shown that there are considerable size variations among these picornaviruses. The diameters ranged from 18 to 25 mμ. Echovirus 19 and poliovirus 1 were significantly larger (mean diameter, 23.5 mμ) than echoviruses 4, 6, 16, and 23, and coxsackievirus B2 (mean diameter, 21.0 mμ).