Tissue distribution of roxithromycin

Publisher Website
Google Scholar
Abstract
As tissue distribution studies have become increasingly important aspects of the assessment of new antimicrobials, roxithromycin distribution has been evaluated in experimental models and in human tissues and body fluids. High levels were achieved in respiratory tract tissues and fluids and in the male and female genital tract In most experiments the local concentrations of roxithromycin were as high as that in serum, reaching 4–6 mg/1 (or mg/kg) or more. These high levels were generally stable and an equilibrium was reached between central and extra-vascular compartments. These data provide important information which may be clinically relevant.

This publication has 0 references indexed in Scilit: