A common neurobiology for pain and pleasure
Top Cited Papers
- 1 April 2008
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 9 (4) , 314-320
- https://doi.org/10.1038/nrn2333
Abstract
Pain and pleasure are powerful motivators of behaviour and have historically been considered opposites. Emerging evidence from the pain and reward research fields points to extensive similarities in the anatomical substrates of painful and pleasant sensations. Recent molecular-imaging and animal studies have demonstrated the important role of the opioid and dopamine systems in modulating both pain and pleasure. Understanding the mutually inhibitory effects that pain and reward processing have on each other, and the neural mechanisms that underpin such modulation, is important for alleviating unnecessary suffering and improving well-being.Keywords
This publication has 119 references indexed in Scilit:
- Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex studyJournal of Neurology, Neurosurgery & Psychiatry, 2007
- Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine rewardProceedings of the National Academy of Sciences, 2007
- The Cerebral Signature for Pain Perception and Its ModulationNeuron, 2007
- Placebo effects on human μ-opioid activity during painProceedings of the National Academy of Sciences, 2007
- Mesolimbic dopaminergic mechanisms and pain controlPAIN®, 2006
- Opponent appetitive-aversive neural processes underlie predictive learning of pain reliefNature Neuroscience, 2005
- Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjectsPain, 2004
- Placebo-Induced Changes in fMRI in the Anticipation and Experience of PainScience, 2004
- Placebo and Opioid Analgesia-- Imaging a Shared Neuronal NetworkScience, 2002
- The misconception of Christian sufferingPastoral Psychology, 1983