The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain

This publication has 34 references indexed in Scilit:

• Nicotinic receptors as targets for therapeutic discovery
  Expert Opinion on Drug Discovery, 2007
• The Novel α7 Nicotinic Acetylcholine Receptor Agonist N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide Improves Working and Recognition Memory in Rodents
  The Journal of Pharmacology and Experimental Therapeutics, 2007
• The β‐amyloid protein of Alzheimer’s disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor
  Journal of Neurochemistry, 2007
• Brain nicotinic acetylcholine receptors: native subtypes and their relevance
  Published by Elsevier ,2006
• The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats
  The Journal of Pharmacology and Experimental Therapeutics, 2005
• Coupling of human nicotinic acetylcholine receptors α7 to calcium channels in GH3 cells
  Neuropharmacology, 2005
• The −2 bp deletion in exon 6 of the ‘alpha 7-like’ nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit
  Molecular Psychiatry, 2002
• Amyloid Peptide Aβ_1‐42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors
  Journal of Neurochemistry, 2000
• The brain α7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21)
  Behavioural Brain Research, 2000
• Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors
  Science, 1998