Sustained Antihypertensive Effect of Captopril Combined with Diuretics and Beta‐adrenergic Blocking Drugs in Patients with Resistant Hypertension

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Abstract
Ten patients with severe hypertension and unsatisfactory blood pressure control during combined therapy with .beta.-adrenergic blocking drugs, diuretics and vasodilators were treated with gradually increasing doses of captopril. Vasodilators were discontinued 24 h prior to captopril administration. Six patients had essential, 2 renal and 2 renovascular hypertension. Mild renal impairment was observed in 4 patients. Captopril effectively decreased blood pressure for 3 h in all patients after the 1st dose. The antihypertensive effect appeared to be triphasic and was sustained in all but 1 patient during 12 mo. of observation. Captopril doses of 25-75 mg t.i.d. [3 times/day) were sufficient to achieve acceptable blood pressure control (RR .ltoreq. 160/100 mm Hg) when given in this mentioned combination. Side-effects were few and tolerable and discontinuation of captopril was not required.