PHARMACOLOGICAL ACTION OF RADIOGRAPHIC CONTRAST-MEDIA REDUCED CEREBROSPINIAL FLUID PRODUCTION IN THE DOG

  • 1 January 1985
    • journal article
    • research article
    • Vol. 232  (1) , 88-93
Abstract
I.v. administration of radiographic constrast media (CM) significantly decreases CSF production as measured by negative pressure collection from a lateral ventricle of the anesthetized dog. This effect has been shown with the conventional ionic CM, sodium diatrizoate, and is now reported for the new nonionic agent, iohexol. Continuous infusion of either agent maintains the decrease. The magnitude of the CM-induced decreased CSF production is proportional to the dose in the range of 1-4 ml/kg. This action of CM cannot be explained by an osmotic mechanism. Two enzymes involved in the elaboration of CSF, carbonic anhydrase and Na+,K+-ATPase, are not inhibited by sodium diatrizoate sufficiently in vitro to explain this action of CM. I.v. CM may require special attention when reduced CSF production would be deleterious.