Potential therapeutic applications of aspirin and other cyclo‐oxygenase inhibitors.

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Abstract
1 The ubiquitous actions of the cyclo‐oxygenase inhibitors are described. 2 These include the inhibitory effect on prostaglandin synthesis and the direct effect of aspirin on lymphocytes and their ability to produce lymphokines. 3 Aspirin reduces some types of platelet aggregation possibly involving inhibition of the precursors of thromboxane A2 and prostacyclin. 4 The therapeutic implications in relation to transient ischaemic attacks, coronary artery disease and reno‐allograft rejection are discussed. 5 The beneficial and adverse effects on the gastro‐intestinal tract are described. 6 The effects of aspirin‐like drugs on the genito‐urinary tract are described with particular reference to their adverse effects on labour and their therapeutic effect on dysmenorrhoea.