Reduction of Gastric Acid Secretion by 10 Mg and 30 Mg Omeprazole Once Daily
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 20 (10) , 1236-1238
- https://doi.org/10.3109/00365528509089282
Abstract
The reduction in gastric acid secretion by 10 mg and 30 mg omeprazole was studied in 12 patients with ulcer disease in a randomized, double-blind, two-way balanced crossover study. A standardized pentagastrin test was performed before the study and 24 h after each treatment period of 6 days. Treatment was followed by a washout period of 7 days. Omeprazole, 30 mg/day, significantly reduced basal acid output (BAO) by 90% and pentagastrin-stimulated acid output (PAO) by 45% (p 0.01), whereas BAO and PAO were not significantly reduced by omeprazole, 10 mg/day.Keywords
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