Comparison Testing of Current (PPD-S1) and Proposed (PPD-S2) Reference Tuberculin Standards
- 1 April 2000
- journal article
- clinical trial
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 161 (4) , 1167-1171
- https://doi.org/10.1164/ajrccm.161.4.9906050
Abstract
Among low-risk subjects, the tests had equally high specificities (PPD-S1, 98.7% and PPD-S2, 98.5%), using a 10-mm cutoff. The number of discordant (negative versus positive) interpretations for PPD-S2, assuming that low-risk subjects who had a > 10 mm reaction to PPD-S1 were truly infected, was low (0.5%) and indis- tinguishable from the rate of discordant interpretations of the same test when read by two different observers (0.8%). The study results indicate that PPD-S2 is qualified to be used as the new U.S. reference standard for PPD tuberculin.Keywords
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