Comparison of Response to Intravenous Injection and Infusion of Secretin in Man

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Abstract
Pure natural secretin (75 U) was administered twice as a rapid intravenous injection and twice as a continuous intravenous one-hour infusion, on different days to each of five healthy young volunteers. The bicarbonate response to infusion of secretin was higher and more sustained than the response to injection. The peak bicarbonate response occurred preferably after stopping the infusion. The bicarbonate response to injection of secretin showed the greatest individual variations whereas the reproducibility was similar for the two modes of administration.