Skeletal muscle NAD + (P) and NADP+‐dependent malic enzyme in Friedreich's ataxia
- 1 June 1983
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 33 (6) , 712
- https://doi.org/10.1212/wnl.33.6.712
Abstract
Malic enzymes were studied in skeletal muscle from seven patients with Friedreich's ataxia (FA) and nine controls. Muscle contained three different malic enzymes. There were two strictly NADP+-dependent enzymes, one in the cytosol and one in mitochondria. These two enzymes are not allosteric. In FA muscle, activity of the mitochondrial NADP+-linked enzyme was significantly low and the cytosol NADP+-linked enzyme was significantly increased. A third malic enzyme, NAD+(P)-dependent, was found in the mitochondrial fraction. That enzyme had allosteric properties, and its activity was about the same in FA and control muscle.This publication has 8 references indexed in Scilit:
- Friedreich ataxiaNeurology, 1982
- Friedreich ataxiaNeurology, 1979
- Function and regulation of mammalian pyruvate dehydrogenase complex. Acetylation, interlipoyl acetyl transfer, and migration of the pyruvate dehydrogenase component.Journal of Biological Chemistry, 1979
- Pyruvate dehydrogenase deficiency in spinocerebellar degenerationsNeurology, 1979
- Relationshiop between phosphorylation and activity of pyruvate dehydrogenase in rat liver mitochondria and the absence of such a relationship for pyruvate carboxylase.Journal of Biological Chemistry, 1978
- Biochemical studies of skeletal muscle mitochondriaArchives of Biochemistry and Biophysics, 1968
- AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIAThe Journal of cell biology, 1967
- PIGEON LIVER MALIC ENZYME .2. ISOLATION CRYSTALLIZATION AND SOME PROPERTIES1967