[Spinal mechanism of the antispastic action of TRH in patients with amyotrophic lateral sclerosis].

  • 1 January 1988
    • journal article
    • abstracts
    • Vol. 144  (11) , 701-3
Abstract
Effects of high-dose TRH on the vibratory inhibition of soleus H-reflex have been studied in 9 patients with amyotrophic lateral sclerosis. In 6 of the 9, TRH induced a significant increase in vibratory inhibition. This suggests that the TRH-induced reduction of spasticity might be due to an increase in presynaptic inhibition acting on Ia fibres.

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