Effects of aspirin on platelet aggregation as a function of dosage and time

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Abstract
There are reports on the effects of high doses of aspirin on the alteration of platelet aggregation. In the study single doses of aspirin ranging from 81-325 mg were given orally to 7 normal [human] subjects. In vitro measurement of platelet aggregation was performed as a function of time. Based on the data, low-dose aspirin (81 mg) inhibits platelet aggregation. Both the rate and extent of platelet aggregation are impaired with low-dose aspirin, but the rate or extent of platelet aggregation did not depend on the size of the dose. Platelet aggregation inhibition by a single dose of aspirin orally (.gtoreq. 81 mg) may be expected to persist for the life of the platelets affected.

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