Use of the Erythrocyte T3-131I Uptake Test for Evaluating Thyroid Function in Rats. Its Application to a Study of the Extrathyroidal Action of Propylthiouracil

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Abstract
The Hamolsky erythrocyte T3-131I uptake test was modified to permit use of reduced volumes of arterialized blood and was found to be a reliable index of metabolic status in rats suitable for performing serial evaluations of individual animals. Results of the erythrocyte T3-131I uptake test, together with observations of activity and growth and determination of gland weight, 131I gland uptake and serum PBI in rats given T3, T4 and PTU, suggest that PTU almost fully inhibited the metabolic effects of daily doses of 10 μg of T4 but had little effect on response to 5 ng of T3. The erythrocyte T3-131I uptake in contrast to the PBI showed direct correlation with “clinical” evaluation of the animals’ metabolic status. (Endocrinology74: 415, 1964)