Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome
- 5 February 1998
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 338 (6) , 347-354
- https://doi.org/10.1056/nejm199802053380602
Abstract
In patients with the acute respiratory distress syndrome, massive alveolar collapse and cyclic lung reopening and overdistention during mechanical ventilation may perpetuate alveolar injury. We determined whether a ventilatory strategy designed to minimize such lung injuries could reduce not only pulmonary complications but also mortality at 28 days in patients with the acute respiratory distress syndrome.Keywords
This publication has 42 references indexed in Scilit:
- Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model.Journal of Clinical Investigation, 1997
- Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: A prospective studyCritical Care Medicine, 1994
- Ventilation of the Acute Respiratory Distress SyndromeAnesthesiology, 1994
- When to stop a clinical trial.BMJ, 1992
- Critical Care Scoring System—New concept based on hemodynamic dataCritical Care Medicine, 1990
- Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndromeIntensive Care Medicine, 1990
- APACHE IICritical Care Medicine, 1985
- Ventilator-induced barotrauma in controlled mechanical ventilation versus intermittent mandatory ventilationCritical Care Medicine, 1983
- Incidence of pulmonary barotrauma in a medical ICUCritical Care Medicine, 1983
- Indomethacin pretreatment in continuous positive-pressure ventilationCritical Care Medicine, 1981