Stimulation of division in mouse 3T3 cells by coculture with embryonic chick limb tissue
Open Access
- 1 April 1985
- journal article
- research article
- Published by The Company of Biologists in Development
- Vol. 86 (1) , 219-226
- https://doi.org/10.1242/dev.86.1.219
Abstract
Two regions of the chick limb bud — the apical ectodermal ridge and the zone of polarizing activity — have been shown to influence cell division and pattern formation during normal development and following surgical manipulation. In this study, using a simple coculture system, together with autoradiography, we have shown that these morphogenetically active regions of the limb bud can stimulate quiescent 3T3 cells to initiate DNA synthesis to a significantly greater degree than comparable but morphogenetically inactive regions of the limb bud.This publication has 19 references indexed in Scilit:
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