Studies on Local Anesthetics. XIX. Local Anesthetic Activity of N-(Dialkylaminoalkyl)benzamides. Physicochemical Measurements on N-(Dialkylaminoalkyl)benzamides and Benzoic Acid.
- 1 January 1960
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 14 (2) , 321-347
- https://doi.org/10.3891/acta.chem.scand.14-0321
Abstract
Local anesthetic properties and LD50 values were evaluated for 26 N-(dialkylaminoalkyl)benzamides. Ionization constants were determined for 26 N-(dialkylaminoalkyl)benzamides, for benzoic acid and all mono, di-, and trimethylbenzoic acids. Ultraviolet spectra were measured on 15 N-(dialkylaminoalkyl)benzamides, 5 dimethyl-, and all trimethylbenzoic acids. The oscillator strength of these compounds for the absorption band at 220-240 m[mu] was determined and a correlation between these values and the ionization constants was found. Infrared spectra were recorded for the two racemates of N-(2-diethylamino-l,2-dimethylethyl)-2-methylbenzamide.This publication has 1 reference indexed in Scilit:
- Beitrag zur kollektiven Behandlung pharmakologischer ReihenversucheNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1931