Neuronal and glial γ‐aminobutyric acid+ transporters are distinct proteins
- 2 March 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 299 (1) , 99-102
- https://doi.org/10.1016/0014-5793(92)80109-t
Abstract
In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to β-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to β-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.Keywords
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