Urinary oxygen pressure in renal parenchymal and vascular disease. Effects of breathing oxygen

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Abstract
Under steady-state conditions in moderate water diuresis, the O2 pressure (P02) of renal pelvic urine in humans was continuously recorded by polarographic methods before, during, and after 100% O2 breathing. A consistent, reproducible response in the quantity and rate of change was found consisting of an initial rise, an intermediate plateau, and a terminal fall. These dominant changes were associated with smaller, transient rebound deflections secondary to the general hemodynamic effects of O2 breathing. Thus, a characteristic well-defined PO2-time curve was demstrated for normal subjects. Equally consistent deviations from the normal pattern were observed in various renal parenchymal and vascular disease. From these data it was concluded that the maximal response of the urinary O2 pressure to 100% O2 breathing, and the time required to produce it, represent a clinically significant indicator of the renal medullary blood flow.

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